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Shakthar Donetsk provided the shock of the night as they overcame Manchester City 2-1 to book a spot in the last 16 of the Champions League at the expense of Napoli.
First-half goals from Bernard and Ismaily were enough to book a second-round berth for the temporarily homeless Ukrainian champions as Napoli fell to defeat away to Feyenoord.
Porto thumped last season's semi-finalists Monaco 5-2 to earn their spot in the knockout stages as Red Bull Leipzig slumped to a 2-1 defeat at home to pool-toppers Besiktas.
Liverpool topped Group E following a record-breaking 7-0 victory over Spartak Moscow at Anfield, a result that saw Sevilla confirmed in second spot despite being held in Maribor.
And Tottenham Hotspur easily overcame APOEL 3-0 to ensure they finished as winners of Group H ahead of Real Madrid, who won 3-2 at home to Borussia Dortmund.
The final line-up for the last 16 draw, which is due to take place in Nyon on Monday, December 11th at 11am Irish time, is as follows: